Clotrimazole Topical Solution - Drug Information
Clotrimazole during pregnancy: indications for use
One of the most effective antifungal drugs is Clotrimazole. Gynecologists prescribe it to combat such an insidious disease as thrush. Clotrimazole belongs to the category of drugs approved for the treatment of this disease during the period of gestation.
Is Clotrimazole suitable for women during pregnancy?
The incidence of thrush during gestation is high. This is due to changes in hormonal levels and a decrease in immunity. In addition, it can occur after taking antibiotics, hypothermia, stress, etc. The disease is characterized by the growth of opportunistic microorganisms - fungi of the genus Candida.
The latter, it should be noted, are always present in the body, but in small quantities. When the number of useful lactobateria decreases, fungi begin to multiply uncontrollably.
The disease can be provoked by wearing thong panties, sexual intercourse with an infected partner, tight-fitting synthetic underwear, diabetes mellitus, taking hormonal drugs, anal-genital and oral-genital intercourse.
Thrush can be an independent disease or occur against the background of another pathology. It is accompanied by a burning sensation, itching in the external genital area, pain during intercourse, curdled white vaginal discharge and urinary disorders.
The drug is a synthetic anti-fungal and antibacterial agent. It is highly effective against yeasts and molds, Trichomonas, dermatophytes and various bacteria: gardnerella, bacteroid, streptococcus and staphylococcus.
There are two ways of using Clotrimazole: external and local. The drug is sold in several forms: ointment, cream, solution and vaginal tablets.
Principle of action: administered in a small dose, it inhibits the synthesis of proteins that are necessary for the progression of thrush; greatNo doses lead to the accumulation of hydrogen peroxide, which leads to the destruction of the cell membranes of the harmful microbe, as a result of which it dies.
The drug is able to accumulate in the stratum corneum of the skin, therefore it works most effectively in the treatment of fungal diseases.
Instructions for the use of clotrimazole suppositories and other forms of the drug during pregnancy
The main active ingredient is clotrimazole. As additional components, candles include: euthanol, span, polysorbate, cestasteryl and benzyl alcohol, synthetic spermaceti, purified water. Vaginal tablets include lactose, corn starch, soda, tartaric acid, aerosil, magnesium stearic acid and, of course, clotrimazole itself. In a solution for external use, in addition to the main active ingredient, isopropyl myristinate, anhydrous ethanol is present. There are no auxiliary components in the ointment, it consists entirely of clotrimazole.
Doctors prescribe this remedy to their patients for a number of indications. For example, vaginal tablets Clotrimazole are indicated in the presence of genital infections provoked by bacteria susceptible to clotrimazole and fungi of the genus Candida. An agent in the form of a cream is often prescribed as a component of the treatment of varicolored lichen, dermatomycosis, and candidiasis vulvovaginitis. The ointment has proven itself most effectively in the fight against mycoses of skin folds, pityriasis versicolor, erythrasma, superficial candidiasis provoked by dermatophytes, other types of yeast and molds, complicated by mycoses.
The solution is most often prescribed for fungal infections of the mucous membranes and skin: with mycoses of the hands / feet, smooth skin of the trunk, skin folds, scalp, candidiasis, erythrasma, paronychia, pityriasis versicolor.
Candles, cream and clotrimazole tablets: how they work during pregnancy
Doctors and those who were treated with this drug confirm its high efficiency. This is what explains the widespread use of this agent in the fight against fungal diseases, even during pregnancy.
The result after application can be noticed in the near future: if the fungal infection is not started, then the tool will cope with it in a matter of days. Otherwise, when the disease has spread significantly or is severe, a local drug is used in combination with other medicines.
Destroying pathogens, the active substance does not manifest itself anywhere else, that is, it acts exclusively on harmful bacteria.
Systemic action of Clotrimazole
The active substance nevertheless enters the blood, but in negligible amounts. Therefore, it does not have a significant impact. But still it has been scientifically proven that defa fraction of the drug still remains in the body and, in addition, it is able to freely penetrate through the placental membrane to the fetus.
A significant danger to the baby in the womb exists only at the initial stage - in the first trimester. This is due to the fact that during this period the formation of organs and tissues occurs.
The instruction says that the drug is prohibited in the first three months of gestation. Since Clotrimazole is not included in the list of vital drugs, treatment with such drugs is postponed until a later date, when the danger to the unborn child is significantly reduced.
Clotrimazole cream and other forms: side effects during pregnancy
If the doctor prescribed vaginal tablets, then after their use, about 3% of the total amount of the active substance will enter the woman's bloodstream. And if you use an ointment or cream, then this number is further reduced. Such amounts of the active substance in the blood cannot have a significant effect on the body, so its use should not cause concern.
The only thing to consider is that the drug is not recommended for use in the first trimester, during breastfeeding and in the presence of liver dysfunctions. In addition, the number of contraindications, of course, includes hypersensitivity to the main active substance and to any of the auxiliary components.
Therapy can cause side effects. For example, allergic reactions are not excluded, which are manifested by itching, burning, rash, peeling and redness of the skin. Also during pregnancy, cramping pains in the lower abdomen may occur. Sexual intercourse during treatment is accompanied by painful sensations caused by irritation of the vaginal mucosa.
Clotrimazole ointment and suppositories: dosage during pregnancy
- Vaginal suppositories and tablets, which can contain 100 - 200 - 500 mg of the active substance, are injected as deep as possible into the vaginal cavity. They put them in the evening, just before going to bed. Usually, the course of therapy lasts 7 days, however, the dosage, like the duration of use, can be prescribed by the attending physician on an individual basis. Pregnant women, when placing a suppository or pill, should use the applicator intended for this purpose. This must be done manually so as not to damage the delicate mucous membranes and cervix;
- Cream and ointment are applied externally. They lubricate the affected areas of the skin, as well as the vulva. The layer of the product should be thin but continuous. The duration of the course of therapy is determined individually, based on the severity of the disease and a number of other parameters;
- The solution is used for rubbing into the skin and nail plates. As a rule, they are treated with the affected areas three times a day for 1 month. It can also be used to treat thrush. In this case, it is injected into the urethra.
Clotrimazole during pregnancy: features of therapy
In the first trimester, this remedy is highly discouraged. At this time, the risk of negative effects on the fetus is very high. At a later date, in the second and third trimester, it is prescribed only according to indications. You can use this antifungal agent only on the recommendation of the gynecologist leading the pregnancy.
The health of a woman and an unborn child, both during therapy and after it, is out of danger. That is why there are no strict contraindications to its use. Despite this, it is not recommended to use it without a doctor's prescription.
Clotrimazole is a drug that is a complex of chemicals, and only a specialist can decide whether the patient needs it or not.